1. People with Mushroom Allergies as Lion’s Mane is a type of medicinal mushroom. 2. Individuals with Asthma or Eosinophilic Conditions because some anecdotal and case reports suggest Lion’s Mane may stimulate eosinophils or exacerbate respiratory inflammation in sensitive individuals. 3. People Taking Blood Thinners or with Bleeding Disorders because Lion’s Mane may have antiplatelet effects, which could increase bleeding risk. [Drugs to watch: Warfarin, aspirin, clopidogrel, NSAIDs (e.g., ibuprofen). Conditions: Hemophilia, recent surgery, peptic ulcers.] 4. Autoimmune Disease Patients as Lion’s Mane may modulate the immune system, which could be risky for people with autoimmune disorders. (Examples: Lupus, multiple sclerosis, rheumatoid arthritis — talk to your doctor before using it.) 5. Pregnant or Breastfeeding Women Why: There's no strong evidence on safety in pregnancy or lactation. Default advice: Avoid unless prescribed or cleared by a healthcare provider. 6. People Scheduled for Surgery as potential to interfere with anesthesia or blood clotting. Advice: Stop use at least 2 weeks before surgery.